STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
INPP5FPhosphatidylinositide phosphatase SAC2 isoform X1. (1131 aa)    
Predicted Functional Partners:
INPP5B
Type II inositol 1,4,5-trisphosphate 5-phosphatase.
 
   
 0.921
PI4KA
Phosphatidylinositol 4-kinase alpha isoform X1; Belongs to the PI3/PI4-kinase family.
     
 0.906
OCRL
Inositol polyphosphate 5-phosphatase OCRL-1.
 
   
 0.905
PLCB4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
     
 0.903
PTEN
Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.
   
 
  0.903
MTMR6
Myotubularin-related protein 6.
     
 0.903
MTMR3
Myotubularin-related protein 3 isoform X1.
     
 0.903
MTMR7
Myotubularin-related protein 7.
     
 0.903
MTMR4
Myotubularin-related protein 4.
     
 0.903
INPP5E
72 kDa inositol polyphosphate 5-phosphatase.
 
   
 0.903
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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