USP7 protein (Ursus maritimus) - STRING interaction network

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Score

USP7

Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family. (1086 aa)

Predicted Functional Partners:

TP53

0.996

UVSSA

0.994

DAXX

0.990

USP11

0.987

FOXO4

0.969

GMPS

0.966

TRIP12

0.966

TRIM27

0.958

FOXO1

0.955

FOXO3

0.955

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DAXX	TP53	ENSUMAP00000016795	ENSUMAP00000023207	Death domain-associated protein 6.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.995
DAXX	USP7	ENSUMAP00000016795	ENSUMAP00000004635	Death domain-associated protein 6.	Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family.	0.990
FOXO1	FOXO3	ENSUMAP00000026699	ENSUMAP00000027234	Forkhead box protein O1.	Forkhead box protein O3.	0.912
FOXO1	FOXO4	ENSUMAP00000026699	ENSUMAP00000030965	Forkhead box protein O1.	Forkhead box protein O4 isoform X1.	0.853
FOXO1	TP53	ENSUMAP00000026699	ENSUMAP00000023207	Forkhead box protein O1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.849
FOXO1	USP7	ENSUMAP00000026699	ENSUMAP00000004635	Forkhead box protein O1.	Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family.	0.955
FOXO3	FOXO1	ENSUMAP00000027234	ENSUMAP00000026699	Forkhead box protein O3.	Forkhead box protein O1.	0.912
FOXO3	FOXO4	ENSUMAP00000027234	ENSUMAP00000030965	Forkhead box protein O3.	Forkhead box protein O4 isoform X1.	0.872
FOXO3	TP53	ENSUMAP00000027234	ENSUMAP00000023207	Forkhead box protein O3.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.833
FOXO3	USP7	ENSUMAP00000027234	ENSUMAP00000004635	Forkhead box protein O3.	Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family.	0.955
FOXO4	FOXO1	ENSUMAP00000030965	ENSUMAP00000026699	Forkhead box protein O4 isoform X1.	Forkhead box protein O1.	0.853
FOXO4	FOXO3	ENSUMAP00000030965	ENSUMAP00000027234	Forkhead box protein O4 isoform X1.	Forkhead box protein O3.	0.872
FOXO4	TP53	ENSUMAP00000030965	ENSUMAP00000023207	Forkhead box protein O4 isoform X1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.783
FOXO4	USP7	ENSUMAP00000030965	ENSUMAP00000004635	Forkhead box protein O4 isoform X1.	Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family.	0.969
GMPS	TP53	ENSUMAP00000015945	ENSUMAP00000023207	GMP synthase [glutamine-hydrolyzing].	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.614
GMPS	USP7	ENSUMAP00000015945	ENSUMAP00000004635	GMP synthase [glutamine-hydrolyzing].	Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family.	0.966
TP53	DAXX	ENSUMAP00000023207	ENSUMAP00000016795	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Death domain-associated protein 6.	0.995
TP53	FOXO1	ENSUMAP00000023207	ENSUMAP00000026699	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Forkhead box protein O1.	0.849
TP53	FOXO3	ENSUMAP00000023207	ENSUMAP00000027234	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Forkhead box protein O3.	0.833
TP53	FOXO4	ENSUMAP00000023207	ENSUMAP00000030965	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Forkhead box protein O4 isoform X1.	0.783