STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRY1Protein sprouty homolog 1 isoform X1. (311 aa)    
Predicted Functional Partners:
CBL
E3 ubiquitin-protein ligase CBL isoform X2.
    
 0.848
CBLB
E3 ubiquitin-protein ligase CBL-B isoform X1.
    
 0.624
CBLC
E3 ubiquitin-protein ligase CBL-C.
    
 0.563
EGFR
Receptor protein-tyrosine kinase.
     
 0.560
EGF
Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
     
 0.553
TGFA
Protransforming growth factor alpha.
     
 0.548
ETV5
LOW QUALITY PROTEIN: ETS translocation variant 5.
      
 0.540
SPRY2
Sprouty RTK signaling antagonist 2.
  
0.537
SH3KBP1
SH3 domain-containing kinase-binding protein 1 isoform X1.
    
  0.529
GRB2
Growth factor receptor-bound protein 2.
    
 
 0.528
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.