STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CMKLR1Chemerin chemokine-like receptor 1. (360 aa)    
Predicted Functional Partners:
RARRES2
Retinoic acid receptor responder protein 2.
      
 0.856
APP
Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]
    
 0.595
ANXA1
Annexin.
    
 0.593
CCL27
C-C motif chemokine ligand 27.
     
 0.473
TMEM184B
Transmembrane protein 184B.
    
 
 0.450
DOK4
Docking protein 4.
      
 0.441
FCRL1
Fc receptor-like protein 1 isoform X1.
  
 
  0.427
CMTM4
CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X1.
      
 0.408
APLP2
Amyloid-like protein 2.
    
 0.405
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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