STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DET1DET1 homolog. (550 aa)    
Predicted Functional Partners:
COP1
E3 ubiquitin-protein ligase RFWD2.
    
 0.981
DDB1
DNA damage-binding protein 1.
    
 0.944
ERCC8
ERCC excision repair 8, CSA ubiquitin ligase complex subunit.
     
  0.900
CUL4B
LOW QUALITY PROTEIN: cullin-4B; Belongs to the cullin family.
    
 0.877
CUL4A
cullin-4A; Belongs to the cullin family.
    
 0.874
ATXN7L3
Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...]
      
 0.763
RBX1
E3 ubiquitin-protein ligase RBX1.
    
 0.667
DDA1
DET1- and DDB1-associated protein 1.
    
 
 0.661
ENSUMAP00000010476
annotation not available
    
 
 0.634
ETV5
LOW QUALITY PROTEIN: ETS translocation variant 5.
    
 
 0.614
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.