STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (150 aa)    
Predicted Functional Partners:
LOC103665388
C-X-C motif chemokine.
   
 
0.982
LOC103662893
C-X-C chemokine receptor type 2.
   
 
 0.964
LOC103662772
LOW QUALITY PROTEIN: C-X-C chemokine receptor type 2-like; Belongs to the G-protein coupled receptor 1 family.
   
 
 0.964
LOC103665389
C-X-C motif chemokine.
   
 
0.961
IL1B
Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.
   
  
 0.954
ACKR1
Atypical chemokine receptor 1.
     
 0.939
NFKB1
Nuclear factor NF-kappa-B p105 subunit isoform X1.
   
 
 0.937
AGTR1
Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family.
     
  0.937
F2R
Proteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family.
     
  0.906
LPAR3
Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family.
     
  0.903
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.