STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPPL2BSignal peptide peptidase-like 2B. (558 aa)    
Predicted Functional Partners:
STK11IP
LOW QUALITY PROTEIN: serine/threonine-protein kinase 11-interacting protein.
   
    0.811
TNF
Tumor necrosis factor; Belongs to the tumor necrosis factor family.
     
 0.782
SPATA5
Spermatogenesis-associated protein 5.
      
 0.642
FAM78A
Family with sequence similarity 78 member A.
      
 0.629
FAM78B
Family with sequence similarity 78 member B.
      
 0.629
TMEM106B
Transmembrane protein 106B isoform X1.
      
 0.599
ADAM10
Disintegrin and metalloproteinase domain-containing protein 10.
   
  
 0.567
FBXO6
F-box only protein 6.
      
 0.544
RUFY4
RUN and FYVE domain-containing protein 4.
      
 0.495
ENSUMAP00000015439
annotation not available
      
 0.439
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.