ART3 protein (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ART3

NAD(P)(+)--arginine ADP-ribosyltransferase. (294 aa)

Predicted Functional Partners:

LIPT1

0.876

KCNE3

0.869

GOLGA7B

0.727

MEAK7

0.717

GALNT18

0.639

DHX32

0.569

MAP3K7CL

0.552

LOC103677963

0.551

ENSUMAP00000020030

0.551

ENSUMAP00000020556

0.551

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ART3	DHX32	ENSUMAP00000010185	ENSUMAP00000007360	NAD(P)(+)--arginine ADP-ribosyltransferase.	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32.	0.569
ART3	ENSUMAP00000020030	ENSUMAP00000010185	ENSUMAP00000020030	NAD(P)(+)--arginine ADP-ribosyltransferase.	annotation not available	0.551
ART3	ENSUMAP00000020556	ENSUMAP00000010185	ENSUMAP00000020556	NAD(P)(+)--arginine ADP-ribosyltransferase.	annotation not available	0.551
ART3	GALNT18	ENSUMAP00000010185	ENSUMAP00000022125	NAD(P)(+)--arginine ADP-ribosyltransferase.	Polypeptide N-acetylgalactosaminyltransferase.	0.639
ART3	GOLGA7B	ENSUMAP00000010185	ENSUMAP00000031185	NAD(P)(+)--arginine ADP-ribosyltransferase.	Golgin subfamily A member 7B.	0.727
ART3	KCNE3	ENSUMAP00000010185	ENSUMAP00000014484	NAD(P)(+)--arginine ADP-ribosyltransferase.	Potassium voltage-gated channel subfamily E regulatory subunit 3.	0.869
ART3	LIPT1	ENSUMAP00000010185	ENSUMAP00000011943	NAD(P)(+)--arginine ADP-ribosyltransferase.	Lipoyltransferase 1, mitochondrial.	0.876
ART3	LOC103677963	ENSUMAP00000010185	ENSUMAP00000005475	NAD(P)(+)--arginine ADP-ribosyltransferase.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.551
ART3	MAP3K7CL	ENSUMAP00000010185	ENSUMAP00000021963	NAD(P)(+)--arginine ADP-ribosyltransferase.	MAP3K7 C-terminal-like protein isoform X1.	0.552
ART3	MEAK7	ENSUMAP00000010185	ENSUMAP00000009983	NAD(P)(+)--arginine ADP-ribosyltransferase.	MTOR associated protein, eak-7 homolog.	0.717
DHX32	ART3	ENSUMAP00000007360	ENSUMAP00000010185	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32.	NAD(P)(+)--arginine ADP-ribosyltransferase.	0.569
DHX32	GOLGA7B	ENSUMAP00000007360	ENSUMAP00000031185	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32.	Golgin subfamily A member 7B.	0.760
DHX32	MEAK7	ENSUMAP00000007360	ENSUMAP00000009983	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32.	MTOR associated protein, eak-7 homolog.	0.735
ENSUMAP00000020030	ART3	ENSUMAP00000020030	ENSUMAP00000010185	annotation not available	NAD(P)(+)--arginine ADP-ribosyltransferase.	0.551
ENSUMAP00000020030	ENSUMAP00000020556	ENSUMAP00000020030	ENSUMAP00000020556	annotation not available	annotation not available	0.400
ENSUMAP00000020030	KCNE3	ENSUMAP00000020030	ENSUMAP00000014484	annotation not available	Potassium voltage-gated channel subfamily E regulatory subunit 3.	0.647
ENSUMAP00000020030	LIPT1	ENSUMAP00000020030	ENSUMAP00000011943	annotation not available	Lipoyltransferase 1, mitochondrial.	0.786
ENSUMAP00000020556	ART3	ENSUMAP00000020556	ENSUMAP00000010185	annotation not available	NAD(P)(+)--arginine ADP-ribosyltransferase.	0.551
ENSUMAP00000020556	ENSUMAP00000020030	ENSUMAP00000020556	ENSUMAP00000020030	annotation not available	annotation not available	0.400
ENSUMAP00000020556	KCNE3	ENSUMAP00000020556	ENSUMAP00000014484	annotation not available	Potassium voltage-gated channel subfamily E regulatory subunit 3.	0.647

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.78

expected number of edges:

10

PPI enrichment p-value:

1.47e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009308

Amine metabolic process

4 of 36

2.14

2.1

7.55e-05

GO:0006576

Cellular biogenic amine metabolic process

3 of 23

2.21

1.45

0.0018

GO:0006596

Polyamine biosynthetic process

2 of 6

2.62

1.0

0.0152

GO:0008152

Metabolic process

11 of 5608

0.39

0.28

0.0281

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016641

Oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

2 of 8

2.49

0.92

0.0210

GO:0030170

Pyridoxal phosphate binding

3 of 65

1.76

0.85

0.0210

GO:0003824

Catalytic activity

11 of 4910

0.44

0.31

0.0210

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13872

Glutamine family amino acid metabolic process, and Arginine biosynthesis

4 of 75

1.82

1.65

0.00034

CL:13868

Mixed, incl. Cellular amino acid biosynthetic process, and Alanine, aspartate and glutamate metabolism

5 of 160

1.59

1.57

0.00021

CL:13937

Aminotransferase class-III, and Pyridoxal-dependent decarboxylase conserved domain

2 of 5

2.7

1.27

0.0050

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00330

Arginine and proline metabolism

6 of 102

1.86

3.24

1.46e-08

map00410

beta-Alanine metabolism

3 of 52

1.86

1.6

0.00051

map00360

Phenylalanine metabolism

3 of 68

1.74

1.45

0.00083

map00270

Cysteine and methionine metabolism

3 of 87

1.63

1.31

0.0014

map00350

Tyrosine metabolism

3 of 134

1.44

1.07

0.0034

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004838

Aminotransferases, class-I, pyridoxal-phosphate-binding site

2 of 3

2.92

0.97

0.0178

IPR002937

Amine oxidase

2 of 8

2.49

0.93

0.0200

IPR015424

Pyridoxal phosphate-dependent transferase

3 of 54

1.84

0.9

0.0178

IPR015421

Pyridoxal phosphate-dependent transferase, major domain

3 of 54

1.84

0.9

0.0178

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (16%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About