LOC103660193 protein (Ursus maritimus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

LOC103660193

LOW QUALITY PROTEIN: tubulin polyglutamylase TTLL13-like. (773 aa)

Predicted Functional Partners:

TTLL5

0.636

OCIAD2

0.522

SNX11

0.521

AGBL5

0.519

UBE2Z

0.518

CEP41

0.513

ENSUMAP00000012619

0.513

KIF21A

0.495

MLXIPL

0.466

LOC103677988

0.452

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGBL5	CEP41	ENSUMAP00000030423	ENSUMAP00000012590	LOW QUALITY PROTEIN: cytosolic carboxypeptidase-like protein 5.	Centrosomal protein of 41 kDa isoform X1.	0.517
AGBL5	ENSUMAP00000012619	ENSUMAP00000030423	ENSUMAP00000012619	LOW QUALITY PROTEIN: cytosolic carboxypeptidase-like protein 5.	annotation not available	0.517
AGBL5	LOC103660193	ENSUMAP00000030423	ENSUMAP00000010713	LOW QUALITY PROTEIN: cytosolic carboxypeptidase-like protein 5.	LOW QUALITY PROTEIN: tubulin polyglutamylase TTLL13-like.	0.519
AGBL5	TTLL5	ENSUMAP00000030423	ENSUMAP00000010207	LOW QUALITY PROTEIN: cytosolic carboxypeptidase-like protein 5.	Tubulin polyglutamylase TTLL5 isoform X2.	0.637
CEP41	AGBL5	ENSUMAP00000012590	ENSUMAP00000030423	Centrosomal protein of 41 kDa isoform X1.	LOW QUALITY PROTEIN: cytosolic carboxypeptidase-like protein 5.	0.517
CEP41	ENSUMAP00000012619	ENSUMAP00000012590	ENSUMAP00000012619	Centrosomal protein of 41 kDa isoform X1.	annotation not available	0.900
CEP41	LOC103660193	ENSUMAP00000012590	ENSUMAP00000010713	Centrosomal protein of 41 kDa isoform X1.	LOW QUALITY PROTEIN: tubulin polyglutamylase TTLL13-like.	0.513
ENSUMAP00000012619	AGBL5	ENSUMAP00000012619	ENSUMAP00000030423	annotation not available	LOW QUALITY PROTEIN: cytosolic carboxypeptidase-like protein 5.	0.517
ENSUMAP00000012619	CEP41	ENSUMAP00000012619	ENSUMAP00000012590	annotation not available	Centrosomal protein of 41 kDa isoform X1.	0.900
ENSUMAP00000012619	LOC103660193	ENSUMAP00000012619	ENSUMAP00000010713	annotation not available	LOW QUALITY PROTEIN: tubulin polyglutamylase TTLL13-like.	0.513
KIF21A	LOC103660193	ENSUMAP00000033505	ENSUMAP00000010713	Kinesin-like protein KIF21A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	LOW QUALITY PROTEIN: tubulin polyglutamylase TTLL13-like.	0.495
KIF21A	LOC103677988	ENSUMAP00000033505	ENSUMAP00000007184	Kinesin-like protein KIF21A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	LOW QUALITY PROTEIN: centromere-associated protein E-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.739
LOC103660193	AGBL5	ENSUMAP00000010713	ENSUMAP00000030423	LOW QUALITY PROTEIN: tubulin polyglutamylase TTLL13-like.	LOW QUALITY PROTEIN: cytosolic carboxypeptidase-like protein 5.	0.519
LOC103660193	CEP41	ENSUMAP00000010713	ENSUMAP00000012590	LOW QUALITY PROTEIN: tubulin polyglutamylase TTLL13-like.	Centrosomal protein of 41 kDa isoform X1.	0.513
LOC103660193	ENSUMAP00000012619	ENSUMAP00000010713	ENSUMAP00000012619	LOW QUALITY PROTEIN: tubulin polyglutamylase TTLL13-like.	annotation not available	0.513
LOC103660193	KIF21A	ENSUMAP00000010713	ENSUMAP00000033505	LOW QUALITY PROTEIN: tubulin polyglutamylase TTLL13-like.	Kinesin-like protein KIF21A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.495
LOC103660193	LOC103677988	ENSUMAP00000010713	ENSUMAP00000007184	LOW QUALITY PROTEIN: tubulin polyglutamylase TTLL13-like.	LOW QUALITY PROTEIN: centromere-associated protein E-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.452
LOC103660193	MLXIPL	ENSUMAP00000010713	ENSUMAP00000018625	LOW QUALITY PROTEIN: tubulin polyglutamylase TTLL13-like.	Carbohydrate-responsive element-binding protein.	0.466
LOC103660193	OCIAD2	ENSUMAP00000010713	ENSUMAP00000002796	LOW QUALITY PROTEIN: tubulin polyglutamylase TTLL13-like.	OCIA domain-containing protein 2.	0.522
LOC103660193	SNX11	ENSUMAP00000010713	ENSUMAP00000021699	LOW QUALITY PROTEIN: tubulin polyglutamylase TTLL13-like.	Sorting nexin-11.	0.521

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.831

expected number of edges:

12

PPI enrichment p-value:

2.24e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000151

Ubiquitin ligase complex

5 of 307

1.43

1.21

0.0011

GO:0031466

Cul5-RING ubiquitin ligase complex

2 of 6

2.74

1.16

0.0080

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:18698375

(2008) Identifying determinants of cullin binding specificity among the three functionally different Drosophila melanogaster Roc proteins via domain swapping.

3 of 13

2.58

1.36

0.0032

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3248

COMM domain, and SOCS box-like domain superfamily

5 of 31

2.42

3.78

4.13e-08

CL:3253

COMM domain

3 of 11

2.65

2.38

3.91e-05

CL:3255

COMM domain

2 of 5

2.82

1.36

0.0034

CL:3284

SOCS box-like domain superfamily

2 of 6

2.74

1.32

0.0040

CL:10434

cullin-RING ubiquitin ligase complex, and Protein neddylation

3 of 87

1.75

1.06

0.0074

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map05170

Human immunodeficiency virus 1 infection

4 of 221

1.47

1.13

0.0025

map04120

Ubiquitin mediated proteolysis

4 of 279

1.37

1.04

0.0031

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8951664

Neddylation

10 of 335

1.69

3.88

1.02e-13

MAP-9705462

Inactivation of CSF3 (G-CSF) signaling

4 of 26

2.4

3.08

1.14e-06

MAP-9674555

Signaling by CSF3 (G-CSF)

4 of 30

2.34

3.0

1.44e-06

MAP-983168

Antigen processing: Ubiquitination & Proteasome degradation

6 of 422

1.37

1.58

2.00e-05

MAP-983169

Class I MHC mediated antigen processing & presentation

6 of 482

1.31

1.45

3.73e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031466

Cul5-RING ubiquitin ligase complex

3 of 7

2.85

2.58

1.91e-05

GOCC:0000151

Ubiquitin ligase complex

6 of 250

1.6

2.03

6.28e-06

GOCC:0070449

Elongin complex

2 of 4

2.92

1.5

0.0019

GOCC:0031461

cullin-RING ubiquitin ligase complex

4 of 152

1.64

1.35

0.0011

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07258

COMM domain

3 of 10

2.69

2.17

0.00010

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017920

COMM domain

3 of 10

2.69

1.91

0.00032

IPR047155

COMM domain-containing protein 4/6/7/8

2 of 4

2.92

0.98

0.0169

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