node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCKDHA | BCKDHB | ENSUMAP00000007276 | ENSUMAP00000022936 | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial isoform X1. | 0.999 |
BCKDHA | CS | ENSUMAP00000007276 | ENSUMAP00000023359 | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | Citrate synthase; Belongs to the citrate synthase family. | 0.890 |
BCKDHA | DHTKD1 | ENSUMAP00000007276 | ENSUMAP00000017873 | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial. | 0.664 |
BCKDHA | DLD | ENSUMAP00000007276 | ENSUMAP00000024834 | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | Dihydrolipoyl dehydrogenase. | 0.997 |
BCKDHA | DLST | ENSUMAP00000007276 | ENSUMAP00000011054 | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | Dihydrolipoamide S-succinyltransferase. | 0.966 |
BCKDHA | OGDH | ENSUMAP00000007276 | ENSUMAP00000013043 | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | 2-oxoglutarate dehydrogenase, mitochondrial. | 0.773 |
BCKDHA | OGDHL | ENSUMAP00000007276 | ENSUMAP00000021813 | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | 2-oxoglutarate dehydrogenase-like, mitochondrial isoform X1. | 0.660 |
BCKDHA | PDHB | ENSUMAP00000007276 | ENSUMAP00000032293 | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.999 |
BCKDHA | PDHX | ENSUMAP00000007276 | ENSUMAP00000024771 | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | 0.962 |
BCKDHA | SUCLG1 | ENSUMAP00000007276 | ENSUMAP00000008067 | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. | 0.673 |
BCKDHB | BCKDHA | ENSUMAP00000022936 | ENSUMAP00000007276 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial isoform X1. | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | 0.999 |
BCKDHB | CS | ENSUMAP00000022936 | ENSUMAP00000023359 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial isoform X1. | Citrate synthase; Belongs to the citrate synthase family. | 0.878 |
BCKDHB | DHTKD1 | ENSUMAP00000022936 | ENSUMAP00000017873 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial isoform X1. | Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial. | 0.714 |
BCKDHB | DLD | ENSUMAP00000022936 | ENSUMAP00000024834 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial isoform X1. | Dihydrolipoyl dehydrogenase. | 0.996 |
BCKDHB | DLST | ENSUMAP00000022936 | ENSUMAP00000011054 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial isoform X1. | Dihydrolipoamide S-succinyltransferase. | 0.963 |
BCKDHB | OGDH | ENSUMAP00000022936 | ENSUMAP00000013043 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial isoform X1. | 2-oxoglutarate dehydrogenase, mitochondrial. | 0.797 |
BCKDHB | OGDHL | ENSUMAP00000022936 | ENSUMAP00000021813 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial isoform X1. | 2-oxoglutarate dehydrogenase-like, mitochondrial isoform X1. | 0.696 |
BCKDHB | PDHB | ENSUMAP00000022936 | ENSUMAP00000032293 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial isoform X1. | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.610 |
BCKDHB | PDHX | ENSUMAP00000022936 | ENSUMAP00000024771 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial isoform X1. | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | 0.962 |
BCKDHB | SUCLG1 | ENSUMAP00000022936 | ENSUMAP00000008067 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial isoform X1. | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. | 0.717 |