TXLNA protein (Ursus maritimus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

TXLNA

LOW QUALITY PROTEIN: alpha-taxilin. (546 aa)

Predicted Functional Partners:

STX3

0.960

STX4

0.956

STX1A

0.922

STX1B

0.902

SERTM1

0.782

CLK3

0.771

TMEM14A

0.756

PPP1R10

0.738

FAM91A1

0.736

SPAG5

0.692

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLK3	PPP1R10	ENSUMAP00000006446	ENSUMAP00000027004	Dual specificity protein kinase CLK3.	LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 1 regulatory subunit 10.	0.683
CLK3	SERTM1	ENSUMAP00000006446	ENSUMAP00000033326	Dual specificity protein kinase CLK3.	Serine-rich and transmembrane domain-containing protein 1.	0.449
CLK3	TXLNA	ENSUMAP00000006446	ENSUMAP00000011320	Dual specificity protein kinase CLK3.	LOW QUALITY PROTEIN: alpha-taxilin.	0.771
FAM91A1	SERTM1	ENSUMAP00000030813	ENSUMAP00000033326	Protein FAM91A1.	Serine-rich and transmembrane domain-containing protein 1.	0.762
FAM91A1	SPAG5	ENSUMAP00000030813	ENSUMAP00000016189	Protein FAM91A1.	LOW QUALITY PROTEIN: sperm-associated antigen 5.	0.628
FAM91A1	TMEM14A	ENSUMAP00000030813	ENSUMAP00000005390	Protein FAM91A1.	Transmembrane protein 14A isoform X1.	0.722
FAM91A1	TXLNA	ENSUMAP00000030813	ENSUMAP00000011320	Protein FAM91A1.	LOW QUALITY PROTEIN: alpha-taxilin.	0.736
PPP1R10	CLK3	ENSUMAP00000027004	ENSUMAP00000006446	LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 1 regulatory subunit 10.	Dual specificity protein kinase CLK3.	0.683
PPP1R10	SERTM1	ENSUMAP00000027004	ENSUMAP00000033326	LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 1 regulatory subunit 10.	Serine-rich and transmembrane domain-containing protein 1.	0.410
PPP1R10	TXLNA	ENSUMAP00000027004	ENSUMAP00000011320	LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 1 regulatory subunit 10.	LOW QUALITY PROTEIN: alpha-taxilin.	0.738
SERTM1	CLK3	ENSUMAP00000033326	ENSUMAP00000006446	Serine-rich and transmembrane domain-containing protein 1.	Dual specificity protein kinase CLK3.	0.449
SERTM1	FAM91A1	ENSUMAP00000033326	ENSUMAP00000030813	Serine-rich and transmembrane domain-containing protein 1.	Protein FAM91A1.	0.762
SERTM1	PPP1R10	ENSUMAP00000033326	ENSUMAP00000027004	Serine-rich and transmembrane domain-containing protein 1.	LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 1 regulatory subunit 10.	0.410
SERTM1	SPAG5	ENSUMAP00000033326	ENSUMAP00000016189	Serine-rich and transmembrane domain-containing protein 1.	LOW QUALITY PROTEIN: sperm-associated antigen 5.	0.752
SERTM1	TMEM14A	ENSUMAP00000033326	ENSUMAP00000005390	Serine-rich and transmembrane domain-containing protein 1.	Transmembrane protein 14A isoform X1.	0.775
SERTM1	TXLNA	ENSUMAP00000033326	ENSUMAP00000011320	Serine-rich and transmembrane domain-containing protein 1.	LOW QUALITY PROTEIN: alpha-taxilin.	0.782
SPAG5	FAM91A1	ENSUMAP00000016189	ENSUMAP00000030813	LOW QUALITY PROTEIN: sperm-associated antigen 5.	Protein FAM91A1.	0.628
SPAG5	SERTM1	ENSUMAP00000016189	ENSUMAP00000033326	LOW QUALITY PROTEIN: sperm-associated antigen 5.	Serine-rich and transmembrane domain-containing protein 1.	0.752
SPAG5	TMEM14A	ENSUMAP00000016189	ENSUMAP00000005390	LOW QUALITY PROTEIN: sperm-associated antigen 5.	Transmembrane protein 14A isoform X1.	0.650
SPAG5	TXLNA	ENSUMAP00000016189	ENSUMAP00000011320	LOW QUALITY PROTEIN: sperm-associated antigen 5.	LOW QUALITY PROTEIN: alpha-taxilin.	0.692

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.917

expected number of edges:

13

PPI enrichment p-value:

0.000104

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007218

Neuropeptide signaling pathway

4 of 96

1.92

1.39

0.0017

GO:0007186

G protein-coupled receptor signaling pathway

8 of 1734

0.96

0.78

0.0017

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005184

Neuropeptide hormone activity

3 of 24

2.4

1.59

0.0011

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:23404625

(2013) Role of neuropeptide FF in central cardiovascular and neuroendocrine regulation.

4 of 10

2.9

2.58

1.96e-05

PMID:32673481

(2020) Neuropeptide FF and Its Receptors: Therapeutic Applications and Ligand Development.

4 of 14

2.75

2.46

3.00e-05

PMID:30413707

(2018) Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling.

4 of 26

2.49

2.01

0.00018

PMID:22709252

(2012) Nonpeptide ligands of neuropeptide FF: current status and structural insights.

3 of 5

3.08

1.74

0.00072

PMID:22708927

(2012) Selective mode of action of guanidine-containing non-peptides at human NPFF receptors.

3 of 6

3.0

1.73

0.00075

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:23904

Orexin and neuropeptides FF and QRFP bind to their respective receptors, and Negative regulation of gonadotropin secretion

3 of 6

3.0

2.59

1.91e-05

CL:23811

Neuropeptide signaling pathway, and Regulation of systemic arterial blood pressure by hormone

5 of 108

1.96

2.42

7.31e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

bta04080

Neuroactive ligand-receptor interaction

5 of 327

1.48

1.55

0.00011

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0027

Amidation

4 of 37

2.33

2.95

1.74e-06

KW-0527

Neuropeptide

3 of 16

2.57

2.49

2.28e-05

KW-0165

Cleavage on pair of basic residues

3 of 123

1.69

1.11

0.0050

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