STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1975 aa)    
Predicted Functional Partners:
UNC79
LOW QUALITY PROTEIN: protein unc-79 homolog.
   
 0.921
SCN1B
Sodium voltage-gated channel beta subunit 1.
   
 0.891
SCN2B
Sodium voltage-gated channel beta subunit 2.
   
 0.872
SCN4B
Sodium channel subunit beta-4.
    
 0.817
SCN3B
Sodium voltage-gated channel beta subunit 3.
   
 0.770
CACNB4
Voltage-dependent L-type calcium channel subunit beta-4.
   
 0.568
CACNA2D1
Voltage-dependent calcium channel subunit alpha-2/delta-1.
   
 0.560
CACNB3
LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-3.
   
 0.551
KCNQ2
Potassium voltage-gated channel subfamily Q member 2.
   
 0.535
SCN4A
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
  
 
0.524
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.