STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMYD4SET and MYND domain-containing protein 4 isoform X1. (832 aa)    
Predicted Functional Partners:
SMYD5
SET and MYND domain-containing protein 5.
      
 0.854
ROGDI
Protein rogdi homolog.
      
 0.831
LANCL1
lanC-like protein 1 isoform X1.
      
 0.780
RTN4RL1
LOW QUALITY PROTEIN: reticulon-4 receptor-like 1.
   
 
 0.779
COPS7A
COP9 signalosome complex subunit 7a.
      
 0.770
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.720
DHRS3
Short-chain dehydrogenase/reductase 3 isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.675
PRPF31
U4/U6 small nuclear ribonucleoprotein Prp31.
   
  
 0.641
ACOX2
Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.
      
 0.635
SETD1B
Histone-lysine N-methyltransferase SETD1B.
    
 0.598
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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