STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KLK13Kallikrein related peptidase 13; Belongs to the peptidase S1 family. (308 aa)    
Predicted Functional Partners:
SPINK6
Serine protease inhibitor Kazal-type 6.
    
 0.911
SERPINB12
Serpin B12; Belongs to the serpin family.
   
 0.790
KRT77
Keratin, type II cytoskeletal 1b; Belongs to the intermediate filament family.
   
 0.626
KRT84
LOW QUALITY PROTEIN: keratin, type II cuticular Hb4; Belongs to the intermediate filament family.
   
 0.572
APP
Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]
    
 0.561
DSG4
Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
    
 0.551
MET
Hepatocyte growth factor receptor.
    
 0.532
MST1R
Macrophage-stimulating protein receptor.
    
 0.532
MADD
MAP kinase-activating death domain protein isoform X1.
      
 0.518
ASPRV1
Retroviral-like aspartic protease 1.
      
 0.518
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.