EVI5 protein (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

EVI5

Ecotropic viral integration site 5 protein homolog isoform X1. (821 aa)

Predicted Functional Partners:

TBC1D7

0.802

TBC1D21

0.774

TBC1D13

0.771

TBC1D22B

0.735

TBC1D19

0.728

TBC1D20

0.722

PGAP3

0.717

TBC1D16

0.644

FBXO8

0.638

ZDHHC9

0.598

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EVI5	FBXO8	ENSUMAP00000015295	ENSUMAP00000030014	Ecotropic viral integration site 5 protein homolog isoform X1.	F-box only protein 8.	0.638
EVI5	PGAP3	ENSUMAP00000015295	ENSUMAP00000023997	Ecotropic viral integration site 5 protein homolog isoform X1.	Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation; Belongs to the PGAP3 family.	0.717
EVI5	TBC1D13	ENSUMAP00000015295	ENSUMAP00000028378	Ecotropic viral integration site 5 protein homolog isoform X1.	TBC1 domain family member 13 isoform X1.	0.771
EVI5	TBC1D16	ENSUMAP00000015295	ENSUMAP00000019482	Ecotropic viral integration site 5 protein homolog isoform X1.	TBC1 domain family member 16.	0.644
EVI5	TBC1D19	ENSUMAP00000015295	ENSUMAP00000005299	Ecotropic viral integration site 5 protein homolog isoform X1.	TBC1 domain family member 19 isoform X1.	0.728
EVI5	TBC1D20	ENSUMAP00000015295	ENSUMAP00000001178	Ecotropic viral integration site 5 protein homolog isoform X1.	TBC1 domain family member 20.	0.722
EVI5	TBC1D21	ENSUMAP00000015295	ENSUMAP00000006749	Ecotropic viral integration site 5 protein homolog isoform X1.	TBC1 domain family member 21 isoform X1.	0.774
EVI5	TBC1D22B	ENSUMAP00000015295	ENSUMAP00000013378	Ecotropic viral integration site 5 protein homolog isoform X1.	TBC1 domain family member 22B isoform X1.	0.735
EVI5	TBC1D7	ENSUMAP00000015295	ENSUMAP00000024654	Ecotropic viral integration site 5 protein homolog isoform X1.	TBC1 domain family member 7.	0.802
EVI5	ZDHHC9	ENSUMAP00000015295	ENSUMAP00000005874	Ecotropic viral integration site 5 protein homolog isoform X1.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.598
FBXO8	EVI5	ENSUMAP00000030014	ENSUMAP00000015295	F-box only protein 8.	Ecotropic viral integration site 5 protein homolog isoform X1.	0.638
PGAP3	EVI5	ENSUMAP00000023997	ENSUMAP00000015295	Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation; Belongs to the PGAP3 family.	Ecotropic viral integration site 5 protein homolog isoform X1.	0.717
TBC1D13	EVI5	ENSUMAP00000028378	ENSUMAP00000015295	TBC1 domain family member 13 isoform X1.	Ecotropic viral integration site 5 protein homolog isoform X1.	0.771
TBC1D13	TBC1D19	ENSUMAP00000028378	ENSUMAP00000005299	TBC1 domain family member 13 isoform X1.	TBC1 domain family member 19 isoform X1.	0.772
TBC1D13	TBC1D20	ENSUMAP00000028378	ENSUMAP00000001178	TBC1 domain family member 13 isoform X1.	TBC1 domain family member 20.	0.526
TBC1D13	TBC1D21	ENSUMAP00000028378	ENSUMAP00000006749	TBC1 domain family member 13 isoform X1.	TBC1 domain family member 21 isoform X1.	0.840
TBC1D13	TBC1D22B	ENSUMAP00000028378	ENSUMAP00000013378	TBC1 domain family member 13 isoform X1.	TBC1 domain family member 22B isoform X1.	0.410
TBC1D13	TBC1D7	ENSUMAP00000028378	ENSUMAP00000024654	TBC1 domain family member 13 isoform X1.	TBC1 domain family member 7.	0.751
TBC1D16	EVI5	ENSUMAP00000019482	ENSUMAP00000015295	TBC1 domain family member 16.	Ecotropic viral integration site 5 protein homolog isoform X1.	0.644
TBC1D16	TBC1D19	ENSUMAP00000019482	ENSUMAP00000005299	TBC1 domain family member 16.	TBC1 domain family member 19 isoform X1.	0.726

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.846

expected number of edges:

14

PPI enrichment p-value:

0.002

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0150011

Regulation of neuron projection arborization

4 of 7

3.04

3.81

1.08e-07

GO:0099560

Synaptic membrane adhesion

4 of 15

2.71

3.33

6.33e-07

GO:0070831

Basement membrane assembly

4 of 15

2.71

3.33

6.33e-07

GO:2001222

Regulation of neuron migration

4 of 25

2.48

3.05

1.55e-06

GO:0034446

Substrate adhesion-dependent cell spreading

4 of 37

2.31

2.74

4.70e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030246

Carbohydrate binding

4 of 223

1.53

0.92

0.0110

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043256

Laminin complex

4 of 13

2.77

3.72

1.21e-07

GO:0098945

Intrinsic component of presynaptic active zone membrane

4 of 14

2.74

3.71

1.21e-07

GO:0046658

Anchored component of plasma membrane

4 of 46

2.22

2.87

1.93e-06

GO:0097060

Synaptic membrane

6 of 326

1.55

2.1

1.61e-06

GO:0098978

Glutamatergic synapse

5 of 216

1.65

2.07

7.53e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5001

Synaptic membrane adhesion, and Receptor-type tyrosine-protein phosphatases

6 of 13

2.94

6.59

4.57e-13

CL:4899

Mixed, incl. Receptor-type tyrosine-protein phosphatases, and Synaptic membrane adhesion

7 of 67

2.3

5.38

3.58e-12

CL:5003

BspA type Leucine rich repeat region, and Regulation of neuron projection arborization

4 of 5

3.18

4.85

1.40e-09

CL:19245

GPCR, family 2, latrophilin, and Teneurin Intracellular Region

3 of 12

2.68

2.65

1.24e-05

CL:19227

Mixed, incl. Olfactomedin-like domains, and Netrin-1 signaling

4 of 73

2.02

2.36

1.31e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04514

Cell adhesion molecules

7 of 251

1.73

3.14

2.40e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-373080

Class B/2 (Secretin family receptors)

4 of 79

1.99

1.93

0.00012

MAP-163125

Post-translational modification: synthesis of GPI-anchored proteins

4 of 90

1.93

1.9

0.00012

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0097060

Synaptic membrane

4 of 152

1.7

1.34

0.0014

GOCC:0043256

Laminin complex

2 of 16

2.38

0.93

0.0193

GOCC:0030054

Cell junction

6 of 919

1.1

0.88

0.0021

GOCC:0099061

Integral component of postsynaptic density membrane

2 of 37

2.01

0.71

0.0465

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1015

Disulfide bond

10 of 1086

1.24

1.9

4.82e-10

KW-0424

Laminin EGF-like domain

2 of 35

2.04

0.99

0.0131

KW-0297

G-protein coupled receptor

4 of 368

1.32

0.95

0.0046

KW-0245

EGF-like domain

3 of 225

1.41

0.85

0.0131

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02354

Latrophilin Cytoplasmic C-terminal region

4 of 6

3.1

4.22

1.95e-08

PF02140

Galactose binding lectin domain

4 of 12

2.8

3.81

8.44e-08

PF16489

GPCR-Autoproteolysis INducing (GAIN) domain

4 of 15

2.71

3.7

1.20e-07

PF02793

Hormone receptor domain

3 of 11

2.72

2.56

1.86e-05

PF00002

7 transmembrane receptor (Secretin family)

4 of 64

2.08

2.34

1.86e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003924

GPCR, family 2, latrophilin

4 of 6

3.1

3.97

5.78e-08

IPR003334

GPCR, family 2, latrophilin, C-terminal

4 of 6

3.1

3.97

5.78e-08

IPR043159

D-galactoside/L-rhamnose binding SUEL lectin domain superfamily

4 of 13

2.77

3.58

2.18e-07

IPR000922

D-galactoside/L-rhamnose binding SUEL lectin domain

4 of 13

2.77

3.58

2.18e-07

IPR032471

GAIN domain, N-terminal

4 of 15

2.71

3.57

2.18e-07

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00284

Olfactomedin-like domains

4 of 21

2.56

3.38

3.99e-07

SM00136

Laminin N-terminal domain (domain VI)

4 of 22

2.54

3.37

3.99e-07

SM00303

G-protein-coupled receptor proteolytic site domain

4 of 35

2.34

3.1

8.61e-07

SM00180

Laminin-type epidermal growth factor-like domai

4 of 39

2.29

3.05

9.67e-07

SM00181

Epidermal growth factor-like domain.

4 of 249

1.49

1.27

0.00099

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