STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PPP1R8Nuclear inhibitor of protein phosphatase 1 isoform X1. (351 aa)    
Predicted Functional Partners:
FAM76A
Protein FAM76A.
      
 0.752
DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.
      
 0.718
DTYMK
Thymidylate kinase.
      
 0.716
FAM76B
Family with sequence similarity 76 member B.
      
 0.700
DNAJC8
DnaJ heat shock protein family (Hsp40) member C8.
   
 
 0.674
PPP1CB
Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.
   
 
 0.669
PPP1CC
Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.
   
 
 0.647
ENSUMAP00000008518
annotation not available
   
 
 0.635
PPP1CA
Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.
   
 
 0.635
POLE3
DNA polymerase epsilon 3, accessory subunit.
   
  
 0.632
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.