GSTK1 protein (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

GSTK1

Glutathione S-transferase kappa. (263 aa)

Predicted Functional Partners:

CYP2E1

0.908

GPX4

0.827

GSTO2

0.827

MGST2

0.823

LOC103679521

0.809

LOC103679616

0.809

LOC103675003

0.809

LOC103675005

0.809

GSTM3

0.809

MGST1

0.803

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP2E1	GSTK1	ENSUMAP00000013980	ENSUMAP00000016154	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family.	Glutathione S-transferase kappa.	0.908
CYP2E1	GSTM3	ENSUMAP00000013980	ENSUMAP00000018424	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family.	Glutathione S-transferase.	0.906
CYP2E1	GSTO2	ENSUMAP00000013980	ENSUMAP00000032849	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family.	Glutathione S-transferase omega-2; Belongs to the GST superfamily.	0.905
CYP2E1	LOC103675003	ENSUMAP00000013980	ENSUMAP00000018410	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family.	Glutathione S-transferase Mu 1 isoform X3; Belongs to the GST superfamily.	0.906
CYP2E1	LOC103675005	ENSUMAP00000013980	ENSUMAP00000018417	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family.	Glutathione S-transferase Mu 1; Belongs to the GST superfamily.	0.906
CYP2E1	LOC103679521	ENSUMAP00000013980	ENSUMAP00000017757	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family.	Glutathione S-transferase P-like; Belongs to the GST superfamily.	0.909
CYP2E1	LOC103679616	ENSUMAP00000013980	ENSUMAP00000017764	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family.	Glutathione S-transferase P-like; Belongs to the GST superfamily.	0.909
CYP2E1	MGST1	ENSUMAP00000013980	ENSUMAP00000003384	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family.	Microsomal Glutathione S-transferase 1.	0.900
CYP2E1	MGST2	ENSUMAP00000013980	ENSUMAP00000020457	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family.	Microsomal glutathione S-transferase 2 isoform X1.	0.902
GPX4	GSTK1	ENSUMAP00000007338	ENSUMAP00000016154	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	Glutathione S-transferase kappa.	0.827
GPX4	GSTM3	ENSUMAP00000007338	ENSUMAP00000018424	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	Glutathione S-transferase.	0.801
GPX4	GSTO2	ENSUMAP00000007338	ENSUMAP00000032849	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	Glutathione S-transferase omega-2; Belongs to the GST superfamily.	0.708
GPX4	LOC103675003	ENSUMAP00000007338	ENSUMAP00000018410	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	Glutathione S-transferase Mu 1 isoform X3; Belongs to the GST superfamily.	0.801
GPX4	LOC103675005	ENSUMAP00000007338	ENSUMAP00000018417	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	Glutathione S-transferase Mu 1; Belongs to the GST superfamily.	0.801
GPX4	LOC103679521	ENSUMAP00000007338	ENSUMAP00000017757	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	Glutathione S-transferase P-like; Belongs to the GST superfamily.	0.800
GPX4	LOC103679616	ENSUMAP00000007338	ENSUMAP00000017764	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	Glutathione S-transferase P-like; Belongs to the GST superfamily.	0.800
GPX4	MGST1	ENSUMAP00000007338	ENSUMAP00000003384	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	Microsomal Glutathione S-transferase 1.	0.674
GPX4	MGST2	ENSUMAP00000007338	ENSUMAP00000020457	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	Microsomal glutathione S-transferase 2 isoform X1.	0.677
GSTK1	CYP2E1	ENSUMAP00000016154	ENSUMAP00000013980	Glutathione S-transferase kappa.	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family.	0.908
GSTK1	GPX4	ENSUMAP00000016154	ENSUMAP00000007338	Glutathione S-transferase kappa.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.827

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.862

expected number of edges:

19

PPI enrichment p-value:

0.537

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006749

Glutathione metabolic process

5 of 39

2.4

3.79

3.56e-08

GO:0006518

Peptide metabolic process

9 of 433

1.61

3.01

2.69e-10

GO:0006572

Tyrosine catabolic process

3 of 6

2.99

2.72

1.13e-05

GO:0006559

L-phenylalanine catabolic process

3 of 9

2.81

2.51

2.54e-05

GO:0006412

Translation

5 of 333

1.47

1.46

0.00020

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004364

Glutathione transferase activity

4 of 16

2.69

3.38

4.76e-07

GO:0003746

Translation elongation factor activity

4 of 24

2.51

3.16

1.00e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005853

Eukaryotic translation elongation factor 1 complex

2 of 2

3.29

1.52

0.0018

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3977

Eukaryotic Translation Elongation, and Translation release factor complex

4 of 6

3.11

4.07

3.70e-08

CL:1155

Tyrosine catabolism, and 4-hydroxyphenylpyruvate dioxygenase

3 of 5

3.07

2.69

1.32e-05

CL:2389

Glutathione S-transferase, C-terminal domain, and Epoxide metabolic process

3 of 10

2.77

2.37

4.49e-05

CL:2393

Glutathione S-transferase, N-terminal domain

2 of 5

2.89

1.61

0.0012

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

tru00982

Drug metabolism - cytochrome P450

3 of 35

2.22

2.0

0.00014

tru00980

Metabolism of xenobiotics by cytochrome P450

3 of 36

2.21

2.0

0.00014

tru00983

Drug metabolism - other enzymes

3 of 57

2.01

1.87

0.00018

tru00480

Glutathione metabolism

3 of 56

2.02

1.87

0.00018

tru01100

Metabolic pathways

5 of 1393

0.84

0.56

0.0130

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-156842

Eukaryotic Translation Elongation

4 of 7

3.05

4.19

2.06e-08

MAP-156590

Glutathione conjugation

4 of 27

2.46

3.14

9.79e-07

MAP-8963684

Tyrosine catabolism

3 of 6

2.99

2.92

4.68e-06

MAP-8963691

Phenylalanine and tyrosine metabolism

3 of 18

2.51

2.33

4.43e-05

MAP-156580

Phase II - Conjugation of compounds

4 of 76

2.01

2.24

2.43e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005853

Eukaryotic translation elongation factor 1 complex

3 of 3

3.29

3.05

3.05e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0251

Elongation factor

4 of 11

2.85

4.18

1.71e-08

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF14497

Glutathione S-transferase, C-terminal domain

5 of 9

3.03

5.55

5.70e-11

PF02798

Glutathione S-transferase, N-terminal domain

4 of 9

2.94

4.07

3.11e-08

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036282

Glutathione S-transferase, C-terminal domain superfamily

6 of 28

2.62

5.44

2.82e-11

IPR004046

Glutathione S-transferase, C-terminal

4 of 12

2.81

3.61

2.09e-07

IPR004045

Glutathione S-transferase, N-terminal

4 of 15

2.71

3.5

2.96e-07

IPR010987

Glutathione S-transferase, C-terminal-like

4 of 20

2.59

3.3

6.08e-07

IPR036219

Translation elongation factor eEF-1beta-like superfamily

3 of 4

3.16

2.96

4.30e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01182

Eukaryotic elongation factor 1 beta central acidic region

3 of 4

3.16

3.07

2.74e-06

SM00888

EF-1 guanine nucleotide exchange domain

3 of 4

3.16

3.07

2.74e-06

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Credits

Access

Info

About

STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About