STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5 isoform X2; Belongs to the protein kinase superfamily. (490 aa)    
Predicted Functional Partners:
MAP3K3
Mitogen-activated protein kinase kinase kinase 3 isoform X1.
  
0.947
MAPK7
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
  
0.929
MAP3K2
Mitogen-activated protein kinase kinase kinase 2 isoform X2.
  
0.913
KSR2
Kinase suppressor of Ras 2.
   
0.772
KSR1
Kinase suppressor of Ras 1.
   
 0.772
RITA1
RBPJ-interacting and tubulin-associated protein 1 isoform X1.
      
 0.771
ARAF
Serine/threonine-protein kinase A-Raf.
   
 0.739
BRAF
Serine/threonine-protein kinase B-raf.
   
0.739
RAF1
RAF proto-oncogene serine/threonine-protein kinase.
   
0.739
MAPK1
Mitogen-activated protein kinase.
   
0.720
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.