STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)    
Predicted Functional Partners:
MAPK1
Mitogen-activated protein kinase.
   
0.995
MAPK3
Mitogen-activated protein kinase.
   
0.988
BRAF
Serine/threonine-protein kinase B-raf.
   
0.986
RAF1
RAF proto-oncogene serine/threonine-protein kinase.
   
0.973
MAPK14
Mitogen-activated protein kinase.
  
0.965
KRAS
GTPase KRas isoform X3.
    
 0.958
MAP3K1
LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1.
   
0.958
HRAS
GTPase HRas isoform X1.
    
 0.956
NRAS
NRAS proto-oncogene, GTPase.
    
 0.956
LAMTOR3
Ragulator complex protein LAMTOR3 isoform X1.
    
 0.948
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.