DCLRE1C protein (Ursus maritimus) - STRING interaction network

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Score

DCLRE1C

Protein artemis isoform X1. (664 aa)

Predicted Functional Partners:

XRCC5

0.980

PRKDC

0.975

XRCC6

0.971

NHEJ1

0.826

MRE11

0.816

TP53BP1

0.779

SYMPK

0.777

ATM

0.768

INTS4

0.762

FIP1L1

0.750

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	DCLRE1C	ENSUMAP00000011132	ENSUMAP00000016848	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein artemis isoform X1.	0.768
ATM	MRE11	ENSUMAP00000011132	ENSUMAP00000009379	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.998
ATM	NHEJ1	ENSUMAP00000011132	ENSUMAP00000026087	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Non-homologous end-joining factor 1 isoform X2.	0.565
ATM	PRKDC	ENSUMAP00000011132	ENSUMAP00000012568	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.792
ATM	TP53BP1	ENSUMAP00000011132	ENSUMAP00000012826	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	LOW QUALITY PROTEIN: tumor suppressor p53-binding protein 1.	0.966
ATM	XRCC5	ENSUMAP00000011132	ENSUMAP00000027789	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.904
ATM	XRCC6	ENSUMAP00000011132	ENSUMAP00000028940	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	X-ray repair cross-complementing protein 6 isoform X1.	0.921
DCLRE1C	ATM	ENSUMAP00000016848	ENSUMAP00000011132	Protein artemis isoform X1.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.768
DCLRE1C	FIP1L1	ENSUMAP00000016848	ENSUMAP00000004238	Protein artemis isoform X1.	pre-mRNA 3'-end-processing factor FIP1.	0.750
DCLRE1C	INTS4	ENSUMAP00000016848	ENSUMAP00000015509	Protein artemis isoform X1.	Integrator complex subunit 4.	0.762
DCLRE1C	MRE11	ENSUMAP00000016848	ENSUMAP00000009379	Protein artemis isoform X1.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.816
DCLRE1C	NHEJ1	ENSUMAP00000016848	ENSUMAP00000026087	Protein artemis isoform X1.	Non-homologous end-joining factor 1 isoform X2.	0.826
DCLRE1C	PRKDC	ENSUMAP00000016848	ENSUMAP00000012568	Protein artemis isoform X1.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.975
DCLRE1C	SYMPK	ENSUMAP00000016848	ENSUMAP00000032892	Protein artemis isoform X1.	Symplekin.	0.777
DCLRE1C	TP53BP1	ENSUMAP00000016848	ENSUMAP00000012826	Protein artemis isoform X1.	LOW QUALITY PROTEIN: tumor suppressor p53-binding protein 1.	0.779
DCLRE1C	XRCC5	ENSUMAP00000016848	ENSUMAP00000027789	Protein artemis isoform X1.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.980
DCLRE1C	XRCC6	ENSUMAP00000016848	ENSUMAP00000028940	Protein artemis isoform X1.	X-ray repair cross-complementing protein 6 isoform X1.	0.971
FIP1L1	DCLRE1C	ENSUMAP00000004238	ENSUMAP00000016848	pre-mRNA 3'-end-processing factor FIP1.	Protein artemis isoform X1.	0.750
FIP1L1	SYMPK	ENSUMAP00000004238	ENSUMAP00000032892	pre-mRNA 3'-end-processing factor FIP1.	Symplekin.	0.997
INTS4	DCLRE1C	ENSUMAP00000015509	ENSUMAP00000016848	Integrator complex subunit 4.	Protein artemis isoform X1.	0.762