STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (396 aa)    
Predicted Functional Partners:
DHCR24
Delta(24)-sterol reductase.
   
 
 0.917
DHCR7
7-dehydrocholesterol reductase.
    
 0.903
APOB
Apolipoprotein B-100.
   
 
 0.876
CH25H
Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.
   
 
 0.872
CYP7A1
Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.
  
 0.825
CYP27A1
Sterol 26-hydroxylase, mitochondrial isoform X1; Belongs to the cytochrome P450 family.
  
 0.812
CYP46A1
Cholesterol 24-hydroxylase; Belongs to the cytochrome P450 family.
  
 0.811
CYP11A1
Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]
  
 0.809
STS
Steryl-sulfatase isoform X1.
   
 
 0.803
SULT2B1
Sulfotransferase; Belongs to the sulfotransferase 1 family.
   
 
 0.802
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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