STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPINT1Kunitz-type protease inhibitor 1. (501 aa)    
Predicted Functional Partners:
ST14
Suppressor of tumorigenicity 14 protein.
   
 0.926
HGF
Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.
    
 0.904
TMPRSS11E
Transmembrane protease serine 11E-like; Belongs to the peptidase S1 family.
   
 0.793
HGFAC
Hepatocyte growth factor activator; Belongs to the peptidase S1 family.
    
 0.728
F12
Coagulation factor XII; Belongs to the peptidase S1 family.
    
 0.705
MST1
Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily.
    
 0.645
NUDT14
LOW QUALITY PROTEIN: uridine diphosphate glucose pyrophosphatase.
      
 0.569
PODXL2
Podocalyxin-like protein 2.
   
 
 0.567
MSH2
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
   
  
 0.547
MLH1
DNA mismatch repair protein Mlh1 isoform X1.
      
 0.545
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.