STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (173 aa)    
Predicted Functional Partners:
VRK3
Inactive serine/threonine-protein kinase VRK3 isoform X1.
    
 0.953
LRP6
Low-density lipoprotein receptor-related protein 6 isoform X1.
    
 0.824
LRP5
Low-density lipoprotein receptor-related protein 5.
    
 0.824
METAP1
Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
   
 
 0.697
ZNF185
Zinc finger protein 185 with LIM domain.
      
 0.646
KDM2A
Lysine-specific demethylase 2A.
    
 
 0.607
SLC39A9
Solute carrier family 39 member 9.
      
 0.602
UBFD1
Ubiquitin domain-containing protein UBFD1.
   
  
 0.592
ENSUMAP00000018664
annotation not available
    
 0.571
LRP2
Low-density lipoprotein receptor-related protein 2.
    
 0.571
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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