ATR protein (Ursus maritimus) - STRING interaction network

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ATR

Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2637 aa)

Predicted Functional Partners:

CHEK1

0.998

ATM

0.998

ATRIP

0.996

CHEK2

0.994

WRN

0.992

FANCM

0.990

ENSUMAP00000000566

0.983

RAD1

0.982

CDC7

0.981

HUS1

0.981

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	ATR	ENSUMAP00000011132	ENSUMAP00000018536	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	0.998
ATM	ATRIP	ENSUMAP00000011132	ENSUMAP00000000543	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	LOW QUALITY PROTEIN: ATR-interacting protein.	0.770
ATM	CHEK1	ENSUMAP00000011132	ENSUMAP00000001841	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase Chk1 isoform X2; Belongs to the protein kinase superfamily.	0.973
ATM	CHEK2	ENSUMAP00000011132	ENSUMAP00000021767	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase Chk2 isoform X2.	0.996
ATM	ENSUMAP00000000566	ENSUMAP00000011132	ENSUMAP00000000566	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	annotation not available	0.770
ATM	FANCM	ENSUMAP00000011132	ENSUMAP00000010245	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	LOW QUALITY PROTEIN: Fanconi anemia group M protein.	0.597
ATM	HUS1	ENSUMAP00000011132	ENSUMAP00000012768	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Checkpoint protein; Belongs to the HUS1 family.	0.773
ATM	RAD1	ENSUMAP00000011132	ENSUMAP00000017573	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cell cycle checkpoint protein RAD1.	0.862
ATM	WRN	ENSUMAP00000011132	ENSUMAP00000009503	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	LOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase.	0.968
ATR	ATM	ENSUMAP00000018536	ENSUMAP00000011132	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.998
ATR	ATRIP	ENSUMAP00000018536	ENSUMAP00000000543	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	LOW QUALITY PROTEIN: ATR-interacting protein.	0.996
ATR	CDC7	ENSUMAP00000018536	ENSUMAP00000001376	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	LOW QUALITY PROTEIN: cell division cycle 7-related protein kinase.	0.981
ATR	CHEK1	ENSUMAP00000018536	ENSUMAP00000001841	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase Chk1 isoform X2; Belongs to the protein kinase superfamily.	0.998
ATR	CHEK2	ENSUMAP00000018536	ENSUMAP00000021767	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase Chk2 isoform X2.	0.994
ATR	ENSUMAP00000000566	ENSUMAP00000018536	ENSUMAP00000000566	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	annotation not available	0.983
ATR	FANCM	ENSUMAP00000018536	ENSUMAP00000010245	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	LOW QUALITY PROTEIN: Fanconi anemia group M protein.	0.990
ATR	HUS1	ENSUMAP00000018536	ENSUMAP00000012768	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Checkpoint protein; Belongs to the HUS1 family.	0.981
ATR	RAD1	ENSUMAP00000018536	ENSUMAP00000017573	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Cell cycle checkpoint protein RAD1.	0.982
ATR	WRN	ENSUMAP00000018536	ENSUMAP00000009503	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	LOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase.	0.992
ATRIP	ATM	ENSUMAP00000000543	ENSUMAP00000011132	LOW QUALITY PROTEIN: ATR-interacting protein.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.770