STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GGHFolate gamma-glutamyl hydrolase. (318 aa)    
Predicted Functional Partners:
FPGS
Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.
     
 0.962
DHFR
Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.
     
 0.935
KLHL32
Kelch-like protein 32 isoform X1.
      
 0.718
ATAD2
ATPase family AAA domain-containing protein 2.
   
  
 0.586
ATIC
Bifunctional purine biosynthesis protein PURH.
      
 0.523
PLBD2
Phospholipase B-like; Putative phospholipase.
      
 0.523
SAE1
SUMO1 activating enzyme subunit 1.
      
 0.521
SPIN3
Spindlin family member 3.
      
 0.520
SPIN1
Spindlin-1 isoform X1.
      
 0.520
RFC1
Replication factor C subunit 1.
      
 0.517
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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