node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATAD2 | GGH | ENSUMAP00000030721 | ENSUMAP00000019182 | ATPase family AAA domain-containing protein 2. | Folate gamma-glutamyl hydrolase. | 0.586 |
ATIC | DHFR | ENSUMAP00000000366 | ENSUMAP00000003526 | Bifunctional purine biosynthesis protein PURH. | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.945 |
ATIC | FPGS | ENSUMAP00000000366 | ENSUMAP00000000568 | Bifunctional purine biosynthesis protein PURH. | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.529 |
ATIC | GGH | ENSUMAP00000000366 | ENSUMAP00000019182 | Bifunctional purine biosynthesis protein PURH. | Folate gamma-glutamyl hydrolase. | 0.523 |
ATIC | RFC1 | ENSUMAP00000000366 | ENSUMAP00000000784 | Bifunctional purine biosynthesis protein PURH. | Replication factor C subunit 1. | 0.501 |
DHFR | ATIC | ENSUMAP00000003526 | ENSUMAP00000000366 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Bifunctional purine biosynthesis protein PURH. | 0.945 |
DHFR | FPGS | ENSUMAP00000003526 | ENSUMAP00000000568 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.987 |
DHFR | GGH | ENSUMAP00000003526 | ENSUMAP00000019182 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Folate gamma-glutamyl hydrolase. | 0.935 |
FPGS | ATIC | ENSUMAP00000000568 | ENSUMAP00000000366 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Bifunctional purine biosynthesis protein PURH. | 0.529 |
FPGS | DHFR | ENSUMAP00000000568 | ENSUMAP00000003526 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.987 |
FPGS | GGH | ENSUMAP00000000568 | ENSUMAP00000019182 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Folate gamma-glutamyl hydrolase. | 0.962 |
FPGS | RFC1 | ENSUMAP00000000568 | ENSUMAP00000000784 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Replication factor C subunit 1. | 0.457 |
GGH | ATAD2 | ENSUMAP00000019182 | ENSUMAP00000030721 | Folate gamma-glutamyl hydrolase. | ATPase family AAA domain-containing protein 2. | 0.586 |
GGH | ATIC | ENSUMAP00000019182 | ENSUMAP00000000366 | Folate gamma-glutamyl hydrolase. | Bifunctional purine biosynthesis protein PURH. | 0.523 |
GGH | DHFR | ENSUMAP00000019182 | ENSUMAP00000003526 | Folate gamma-glutamyl hydrolase. | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.935 |
GGH | FPGS | ENSUMAP00000019182 | ENSUMAP00000000568 | Folate gamma-glutamyl hydrolase. | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.962 |
GGH | KLHL32 | ENSUMAP00000019182 | ENSUMAP00000029872 | Folate gamma-glutamyl hydrolase. | Kelch-like protein 32 isoform X1. | 0.718 |
GGH | PLBD2 | ENSUMAP00000019182 | ENSUMAP00000014666 | Folate gamma-glutamyl hydrolase. | Phospholipase B-like; Putative phospholipase. | 0.523 |
GGH | RFC1 | ENSUMAP00000019182 | ENSUMAP00000000784 | Folate gamma-glutamyl hydrolase. | Replication factor C subunit 1. | 0.517 |
GGH | SAE1 | ENSUMAP00000019182 | ENSUMAP00000032978 | Folate gamma-glutamyl hydrolase. | SUMO1 activating enzyme subunit 1. | 0.521 |