STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DMC1Meiotic recombination protein DMC1/LIM15 homolog isoform X2; Belongs to the RecA family. (262 aa)    
Predicted Functional Partners:
RAD51
DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]
  
0.928
WRN
LOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase.
  
 0.914
XRCC3
DNA repair protein XRCC3.
  
 0.871
XRCC2
X-ray repair cross complementing 2.
   
 0.868
RAD51B
DNA repair protein RAD51 homolog 2 isoform X1.
  
 0.849
BRCA2
LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.
   
 0.823
REC8
LOW QUALITY PROTEIN: meiotic recombination protein REC8 homolog.
   
 
 0.817
ENSUMAP00000034581
annotation not available
   
 0.811
SPO11
Meiotic recombination protein SPO11 isoform X1.
    
 0.809
RAD51D
DNA repair protein RAD51 homolog 4.
   
 0.762
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.