STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TIGARFructose-2,6-bisphosphatase TIGAR. (211 aa)    
Predicted Functional Partners:
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.966
PFKFB4
6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 isoform X1.
    
 0.960
HK2
LOW QUALITY PROTEIN: hexokinase-2.
   
 0.953
FBP2
Fructose-1,6-bisphosphatase isozyme 2 isoform X1; Belongs to the FBPase class 1 family.
   
 
 0.953
HK1
Hexokinase-1.
   
 0.951
PFKFB1
6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1 isoform X2.
    
 0.948
PFKFB2
6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform X5.
    
 0.945
HKDC1
Hexokinase domain containing 1.
   
 0.938
HK3
Hexokinase-3 isoform X2.
   
 0.927
FBP1
Fructose-1,6-bisphosphatase 1; Belongs to the FBPase class 1 family.
   
 
 0.924
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.