STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADAMTS5A disintegrin and metalloproteinase with thrombospondin motifs 5. (809 aa)    
Predicted Functional Partners:
BCAN
Brevican core protein.
     
 0.929
ADAMTS9
A disintegrin and metalloproteinase with thrombospondin motifs 9.
 
   
 0.853
ACAN
LOW QUALITY PROTEIN: aggrecan core protein.
     
 0.820
MMP13
Collagenase 3.
   
 
 0.780
TIMP3
TIMP metallopeptidase inhibitor 3.
    
 
 0.668
LOC103662452
Stromelysin-1.
   
 
 0.658
IL1B
Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.
      
 0.636
MMP12
Matrix metallopeptidase 12.
   
 
 0.607
TMEM132B
Transmembrane protein 132B.
      
 0.586
COL10A1
LOW QUALITY PROTEIN: collagen alpha-1(X) chain.
    
 0.567
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.