STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DYRK4Dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X2. (519 aa)    
Predicted Functional Partners:
AAR2
Protein AAR2 homolog isoform X1.
      
 0.758
DCAF7
DDB1- and CUL4-associated factor 7.
   
 
 0.679
RIPK2
LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 2.
    
 
 0.652
RNH1
LOW QUALITY PROTEIN: ribonuclease inhibitor.
    
 
 0.651
NFKBIL1
NF-kappa-B inhibitor-like protein 1 isoform X1.
   
  
 0.640
TRAPPC2L
Trafficking protein particle complex subunit 2-like protein isoform X3.
      
 0.636
LOC103659828
Ras-related protein Rap-1b-like.
    
 
 0.619
RAP1B
Ras-related protein Rap-1b.
    
 
 0.619
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.583
RCAN3
Calcipressin-3.
    
 
 0.579
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.