STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PCDH18Protocadherin-18 isoform X2. (1134 aa)    
Predicted Functional Partners:
NAP1L4
Nucleosome assembly protein 1-like 4 isoform X1; Belongs to the nucleosome assembly protein (NAP) family.
   
  
 0.587
RACGAP1
Rac GTPase-activating protein 1.
   
 
 0.545
SCUBE1
Signal peptide, CUB and EGF-like domain-containing protein 1.
    
 0.469
GLIPR2
Golgi-associated plant pathogenesis-related protein 1 isoform X2; Belongs to the CRISP family.
      
 0.454
RHBDF1
Inactive rhomboid protein 1.
   
 
 0.419
RHBDL2
Rhomboid-related protein 2; Belongs to the peptidase S54 family.
   
 
 0.417
MPDZ
Multiple PDZ domain protein isoform X1.
   
 
 0.409
ABI2
Abl interactor 2 isoform X1.
    
 0.405
DRAXIN
Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
      
 0.405
SNED1
Sushi, nidogen and EGF-like domain-containing protein 1.
    
 0.403
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.