STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NF1Neurofibromin. (2862 aa)    
Predicted Functional Partners:
KRAS
GTPase KRas isoform X3.
   
 0.999
SPRED1
Sprouty-related, EVH1 domain-containing protein 1.
    
 0.996
HRAS
GTPase HRas isoform X1.
   
 0.978
NRAS
NRAS proto-oncogene, GTPase.
   
 0.978
RRAS
Ras-related protein R-Ras.
   
 0.965
RRAS2
LOW QUALITY PROTEIN: ras-related protein R-Ras2.
   
 0.951
SPRED2
Sprouty-related, EVH1 domain-containing protein 2.
    
 0.886
MAD2L1
Mitotic spindle assembly checkpoint protein MAD2A isoform X2.
   
 0.865
ANAPC4
Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.
    
 0.839
CDC27
Cell division cycle protein 27 homolog isoform X1.
    
 0.833
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.