STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NFE2L2Nuclear factor erythroid 2-related factor 2 isoform X2. (590 aa)    
Predicted Functional Partners:
KEAP1
Kelch-like ECH-associated protein 1.
    
 0.999
DDIT3
DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]
   
 0.938
GSK3B
Glycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily.
    
 0.935
EIF2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3.
   
 0.928
PARK7
Parkinsonism associated deglycase.
     
 0.923
EIF2AK2
Interferon-induced, double-stranded RNA-activated protein kinase.
   
 0.919
MAPK7
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
   
 0.913
EIF2AK4
Eukaryotic translation initiation factor 2-alpha kinase 4.
     
 0.906
EIF2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1.
     
 0.901
KLHL17
Kelch-like protein 17.
    
 0.886
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.