STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NCOA4Nuclear receptor coactivator 4. (625 aa)    
Predicted Functional Partners:
AR
Androgen receptor.
    
 
 0.949
FTH1-2
Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
   
 0.942
CCDC6
Coiled-coil domain-containing protein 6.
     
 0.942
FTL
Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
   
 0.937
RET
Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.
    
 0.937
VDAC2
Voltage-dependent anion-selective channel protein 2.
      
 0.583
NBR1
Next to BRCA1 gene 1 protein isoform X1.
   
  
 0.558
IREB2
LOW QUALITY PROTEIN: iron-responsive element-binding protein 2; Belongs to the aconitase/IPM isomerase family.
      
 0.552
TUSC3
Tumor suppressor candidate 3.
      
 0.536
LPCAT3
Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family.
      
 0.512
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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