STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (361 aa)    
Predicted Functional Partners:
CDK5R1
Cyclin-dependent kinase 5 activator 1.
    
 0.998
CDK5R2
Cyclin-dependent kinase 5 activator 2.
    
 0.990
PPP1R1B
Protein phosphatase 1 regulatory inhibitor subunit 1B.
    
 0.986
DPYSL2
Dihydropyrimidinase-related protein 2.
     
 0.947
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.888
MAPT
Microtubule associated protein tau.
    
 
 0.867
CABLES1
CDK5 and ABL1 enzyme substrate 1.
    
 0.777
CCNI
cyclin-I; Belongs to the cyclin family.
    
 
 0.736
CRMP1
Dihydropyrimidinase-related protein 1.
     
 0.708
SEMA3A
Semaphorin-3A; Belongs to the semaphorin family.
     
 0.678
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.