AVEN protein (Ursus maritimus) - STRING interaction network

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AVEN

Cell death regulator Aven. (289 aa)

Predicted Functional Partners:

APAF1

0.903

TTC7B

0.635

APOL6

0.635

APIP

0.603

FBXL20

0.598

GREM1

0.559

CST3

0.547

CST3-2

0.547

CSTA

0.547

BNIP5

0.538

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	APIP	ENSUMAP00000007241	ENSUMAP00000024799	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily.	0.850
APAF1	AVEN	ENSUMAP00000007241	ENSUMAP00000023061	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cell death regulator Aven.	0.903
APAF1	BNIP5	ENSUMAP00000007241	ENSUMAP00000013574	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein C6orf222 homolog.	0.601
APIP	APAF1	ENSUMAP00000024799	ENSUMAP00000007241	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.850
APIP	AVEN	ENSUMAP00000024799	ENSUMAP00000023061	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily.	Cell death regulator Aven.	0.603
APIP	CST3	ENSUMAP00000024799	ENSUMAP00000005284	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily.	Cystatin C.	0.406
APIP	CST3-2	ENSUMAP00000024799	ENSUMAP00000034547	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily.	cystatin-C; Belongs to the cystatin family.	0.406
APIP	CSTA	ENSUMAP00000024799	ENSUMAP00000035084	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily.	cystatin-A isoform X1; Belongs to the cystatin family.	0.406
APOL6	AVEN	ENSUMAP00000023020	ENSUMAP00000023061	Apolipoprotein L6.	Cell death regulator Aven.	0.635
AVEN	APAF1	ENSUMAP00000023061	ENSUMAP00000007241	Cell death regulator Aven.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.903
AVEN	APIP	ENSUMAP00000023061	ENSUMAP00000024799	Cell death regulator Aven.	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily.	0.603
AVEN	APOL6	ENSUMAP00000023061	ENSUMAP00000023020	Cell death regulator Aven.	Apolipoprotein L6.	0.635
AVEN	BNIP5	ENSUMAP00000023061	ENSUMAP00000013574	Cell death regulator Aven.	Uncharacterized protein C6orf222 homolog.	0.538
AVEN	CST3	ENSUMAP00000023061	ENSUMAP00000005284	Cell death regulator Aven.	Cystatin C.	0.547
AVEN	CST3-2	ENSUMAP00000023061	ENSUMAP00000034547	Cell death regulator Aven.	cystatin-C; Belongs to the cystatin family.	0.547
AVEN	CSTA	ENSUMAP00000023061	ENSUMAP00000035084	Cell death regulator Aven.	cystatin-A isoform X1; Belongs to the cystatin family.	0.547
AVEN	FBXL20	ENSUMAP00000023061	ENSUMAP00000023799	Cell death regulator Aven.	F-box/LRR-repeat protein 20 isoform X1.	0.598
AVEN	GREM1	ENSUMAP00000023061	ENSUMAP00000021750	Cell death regulator Aven.	Gremlin.	0.559
AVEN	TTC7B	ENSUMAP00000023061	ENSUMAP00000008303	Cell death regulator Aven.	Tetratricopeptide repeat protein 7B.	0.635
BNIP5	APAF1	ENSUMAP00000013574	ENSUMAP00000007241	Uncharacterized protein C6orf222 homolog.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.601