STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SELLL-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (400 aa)    
Predicted Functional Partners:
CD34
Hematopoietic progenitor cell antigen CD34.
   
 
 0.989
LOC103675569
Glycosylation-dependent cell adhesion molecule 1-like.
   
 
 0.985
CD44
CD44 antigen isoform X7.
   
 0.882
SELPLG
P-selectin glycoprotein ligand 1.
   
 0.796
SELP
P-selectin isoform X1.
  
 
0.795
CCR7
LOW QUALITY PROTEIN: C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.782
CD4
T-cell surface glycoprotein CD4.
    
 0.781
CD19
LOW QUALITY PROTEIN: B-lymphocyte antigen CD19.
   
 0.772
IFNG
Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
   
  
 0.767
SELE
E-selectin.
  
 
0.762
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.