STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)    
Predicted Functional Partners:
CCND1
G1/S-specific cyclin-D1.
   
 0.999
CCND3
G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family.
   
 0.999
CCND2
G1/S-specific cyclin-D2; Belongs to the cyclin family.
   
 0.999
RB1
Retinoblastoma-associated protein.
   
 0.998
CDKN2C
Cyclin-dependent kinase 4 inhibitor C.
   
 0.998
CCNE1
G1/S-specific cyclin-E1; Belongs to the cyclin family.
   
 0.996
CDKN2B
Ankyrin repeat domain-containing protein 34A-like.
    
 0.994
CDKN1B
Cyclin-dependent kinase inhibitor 1B.
   
 0.993
CDK6
Cyclin-dependent kinase 6.
  
 
0.993
CDC37
Hsp90 co-chaperone Cdc37.
    
 
 0.979
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.