C12orf66 protein (Ursus maritimus) - STRING interaction network

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[Homology]

Score

C12orf66

LOW QUALITY PROTEIN: UPF0536 protein C12orf66 homolog. (439 aa)

Predicted Functional Partners:

ITFG2

0.999

KPTN

0.998

DEPDC5

0.993

NPRL2

0.991

WDR24

0.987

WDR59

0.985

BMT2

0.886

NPRL3

0.879

MIOS

0.862

CASTOR2

0.737

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMT2	C12orf66	ENSUMAP00000009396	ENSUMAP00000028056	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	LOW QUALITY PROTEIN: UPF0536 protein C12orf66 homolog.	0.886
BMT2	CASTOR2	ENSUMAP00000009396	ENSUMAP00000020450	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	GATS-like protein 2.	0.578
BMT2	DEPDC5	ENSUMAP00000009396	ENSUMAP00000021602	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	DEP domain-containing protein 5.	0.887
BMT2	ITFG2	ENSUMAP00000009396	ENSUMAP00000019986	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Integrin-alpha FG-GAP repeat-containing protein 2.	0.861
BMT2	KPTN	ENSUMAP00000009396	ENSUMAP00000033034	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	LOW QUALITY PROTEIN: kaptin.	0.854
BMT2	MIOS	ENSUMAP00000009396	ENSUMAP00000029763	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	WD repeat-containing protein mio isoform X2.	0.406
BMT2	NPRL2	ENSUMAP00000009396	ENSUMAP00000030195	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Nitrogen permease regulator 2-like protein isoform X1.	0.788
BMT2	NPRL3	ENSUMAP00000009396	ENSUMAP00000028891	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Nitrogen permease regulator 3-like protein isoform X2.	0.819
BMT2	WDR24	ENSUMAP00000009396	ENSUMAP00000029150	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	WD repeat-containing protein 24-like.	0.427
BMT2	WDR59	ENSUMAP00000009396	ENSUMAP00000019490	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	WD repeat-containing protein 59 isoform X2.	0.426
C12orf66	BMT2	ENSUMAP00000028056	ENSUMAP00000009396	LOW QUALITY PROTEIN: UPF0536 protein C12orf66 homolog.	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	0.886
C12orf66	CASTOR2	ENSUMAP00000028056	ENSUMAP00000020450	LOW QUALITY PROTEIN: UPF0536 protein C12orf66 homolog.	GATS-like protein 2.	0.737
C12orf66	DEPDC5	ENSUMAP00000028056	ENSUMAP00000021602	LOW QUALITY PROTEIN: UPF0536 protein C12orf66 homolog.	DEP domain-containing protein 5.	0.993
C12orf66	ITFG2	ENSUMAP00000028056	ENSUMAP00000019986	LOW QUALITY PROTEIN: UPF0536 protein C12orf66 homolog.	Integrin-alpha FG-GAP repeat-containing protein 2.	0.999
C12orf66	KPTN	ENSUMAP00000028056	ENSUMAP00000033034	LOW QUALITY PROTEIN: UPF0536 protein C12orf66 homolog.	LOW QUALITY PROTEIN: kaptin.	0.998
C12orf66	MIOS	ENSUMAP00000028056	ENSUMAP00000029763	LOW QUALITY PROTEIN: UPF0536 protein C12orf66 homolog.	WD repeat-containing protein mio isoform X2.	0.862
C12orf66	NPRL2	ENSUMAP00000028056	ENSUMAP00000030195	LOW QUALITY PROTEIN: UPF0536 protein C12orf66 homolog.	Nitrogen permease regulator 2-like protein isoform X1.	0.991
C12orf66	NPRL3	ENSUMAP00000028056	ENSUMAP00000028891	LOW QUALITY PROTEIN: UPF0536 protein C12orf66 homolog.	Nitrogen permease regulator 3-like protein isoform X2.	0.879
C12orf66	WDR24	ENSUMAP00000028056	ENSUMAP00000029150	LOW QUALITY PROTEIN: UPF0536 protein C12orf66 homolog.	WD repeat-containing protein 24-like.	0.987
C12orf66	WDR59	ENSUMAP00000028056	ENSUMAP00000019490	LOW QUALITY PROTEIN: UPF0536 protein C12orf66 homolog.	WD repeat-containing protein 59 isoform X2.	0.985