STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PDGFRLPlatelet-derived growth factor receptor-like protein. (375 aa)    
Predicted Functional Partners:
VEGFA
Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family.
    
 0.702
PDGFB
Platelet-derived growth factor subunit B.
   
 0.612
VEGFC
Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.
    
 0.595
GRB2
Growth factor receptor-bound protein 2.
   
 0.592
NRP2
Neuropilin; Belongs to the neuropilin family.
     
 0.568
PLCG1
Phosphoinositide phospholipase C.
    
 0.565
NRP1
Neuropilin; Belongs to the neuropilin family.
    
 0.565
ROR1
Tyrosine-protein kinase transmembrane receptor ROR1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
    
 0.553
PDGFRB
Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.
   
0.538
FANK1
Fibronectin type 3 and ankyrin repeat domains protein 1.
    
 0.534
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.