STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)    
Predicted Functional Partners:
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.998
RB1
Retinoblastoma-associated protein.
    
 0.965
AKT3
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.962
AKT2
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.962
AKT1
Non-specific serine/threonine protein kinase.
    
 0.962
USP7
Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family.
    
 0.943
RPL11
60S ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family.
    
 
 0.939
WWP1
E3 ubiquitin-protein ligase.
    
 0.938
IRF1
Interferon regulatory factor.
    
 0.925
ITCH
E3 ubiquitin-protein ligase.
    
 0.923
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.