STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IL18R1Interleukin-18 receptor 1. (452 aa)    
Predicted Functional Partners:
IL18
Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.
   
 0.994
IL18RAP
Interleukin-18 receptor accessory protein isoform X1.
     
 
0.900
IL2RA
Interleukin-2 receptor subunit alpha isoform X1.
   
  
 0.539
ORMDL3
ORMDL sphingolipid biosynthesis regulator 3.
      
 0.519
AAGAB
Alpha- and gamma-adaptin-binding protein p34.
   
  
 0.516
IL12RB2
Interleukin-12 receptor subunit beta-2.
   
  
 0.492
PGAP3
Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation; Belongs to the PGAP3 family.
      
 0.489
ICOS
Inducible T-cell costimulator isoform X1.
   
  
 0.488
FCRL5
Fc receptor-like protein 5.
  
 
 0.477
IL7R
Interleukin-7 receptor subunit alpha.
   
  
 0.446
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.