STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BAP1Ubiquitin carboxyl-terminal hydrolase. (741 aa)    
Predicted Functional Partners:
HCFC2
Host cell factor C2.
    
 0.977
BARD1
BRCA1-associated RING domain protein 1.
    
 0.971
ASXL2
LOW QUALITY PROTEIN: putative Polycomb group protein ASXL2.
    
 0.968
ASXL1
Putative Polycomb group protein ASXL1.
    
 0.960
ASXL3
LOW QUALITY PROTEIN: putative Polycomb group protein ASXL3.
    
 0.929
PSMD4
26S proteasome non-ATPase regulatory subunit 4.
    
 0.929
PSMD8
26S proteasome non-ATPase regulatory subunit 8.
   
 0.918
PSMD2
26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.
   
 0.909
PSMD11
26S proteasome non-ATPase regulatory subunit 11.
   
 0.898
PSMD7
LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 7.
   
 0.897
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.