STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SLIT1LOW QUALITY PROTEIN: slit homolog 1 protein. (1320 aa)    
Predicted Functional Partners:
ENSUMAP00000018033
annotation not available
   
 0.871
ROBO2
Roundabout homolog 2.
   
 0.871
ROBO2-2
Roundabout, axon guidance receptor 2.
   
 0.871
ROBO4
LOW QUALITY PROTEIN: roundabout homolog 4.
   
 0.843
SEMA3F
semaphorin-3F; Belongs to the semaphorin family.
      
 0.787
DRAXIN
Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
      
 0.720
ROBO1
Roundabout homolog 1.
   
 0.689
ADGRL1
Latrophilin-1; Belongs to the G-protein coupled receptor 2 family.
   
 
 0.637
ADGRL2
Latrophilin-2; Belongs to the G-protein coupled receptor 2 family.
   
 
 0.637
EFNB2
Ephrin-B2; Belongs to the ephrin family.
      
 0.637
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.