STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSUMAP00000030752Polyubiquitin-like. (77 aa)    
Predicted Functional Partners:
RPS27A
ubiquitin-40S ribosomal protein S27a.
  
 
0.989
UBA52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
  
0.986
UBE2K
Ubiquitin-conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.946
PSMD4
26S proteasome non-ATPase regulatory subunit 4.
   
 0.946
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.939
RNF8
E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]
   
 0.936
IKBKG
NF-kappa-B essential modulator.
   
 0.924
UBE2N
Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.915
ENSUMAP00000006650
annotation not available
   
 0.915
LOC103669669-2
Ubiquitin-conjugating enzyme E2 variant 1 isoform X2.
   
 0.909
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.