BRIP1 protein (Ursus maritimus) - STRING interaction network

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Score

BRIP1

Fanconi anemia group J protein. (1262 aa)

Predicted Functional Partners:

TOPBP1

0.993

BRCA1

0.977

PALB2

0.966

BRCA2

0.964

PMS2

0.949

SLF1

0.929

BARD1

0.921

WRN

0.882

MNAT1

0.858

GTF2H1

0.853

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BARD1	BRCA1	ENSUMAP00000000975	ENSUMAP00000034948	BRCA1-associated RING domain protein 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.999
BARD1	BRCA2	ENSUMAP00000000975	ENSUMAP00000030927	BRCA1-associated RING domain protein 1.	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	0.967
BARD1	BRIP1	ENSUMAP00000000975	ENSUMAP00000030915	BRCA1-associated RING domain protein 1.	Fanconi anemia group J protein.	0.921
BARD1	PALB2	ENSUMAP00000000975	ENSUMAP00000011908	BRCA1-associated RING domain protein 1.	Partner and localizer of BRCA2 isoform X1.	0.955
BARD1	SLF1	ENSUMAP00000000975	ENSUMAP00000007136	BRCA1-associated RING domain protein 1.	Ankyrin repeat domain-containing protein 32 isoform X2.	0.962
BARD1	TOPBP1	ENSUMAP00000000975	ENSUMAP00000021681	BRCA1-associated RING domain protein 1.	DNA topoisomerase 2-binding protein 1 isoform X1.	0.986
BARD1	WRN	ENSUMAP00000000975	ENSUMAP00000009503	BRCA1-associated RING domain protein 1.	LOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase.	0.954
BRCA1	BARD1	ENSUMAP00000034948	ENSUMAP00000000975	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA1-associated RING domain protein 1.	0.999
BRCA1	BRCA2	ENSUMAP00000034948	ENSUMAP00000030927	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	0.996
BRCA1	BRIP1	ENSUMAP00000034948	ENSUMAP00000030915	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Fanconi anemia group J protein.	0.977
BRCA1	PALB2	ENSUMAP00000034948	ENSUMAP00000011908	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Partner and localizer of BRCA2 isoform X1.	0.995
BRCA1	PMS2	ENSUMAP00000034948	ENSUMAP00000012008	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	PMS1 homolog 2, mismatch repair system component.	0.640
BRCA1	SLF1	ENSUMAP00000034948	ENSUMAP00000007136	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Ankyrin repeat domain-containing protein 32 isoform X2.	0.838
BRCA1	TOPBP1	ENSUMAP00000034948	ENSUMAP00000021681	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA topoisomerase 2-binding protein 1 isoform X1.	0.960
BRCA1	WRN	ENSUMAP00000034948	ENSUMAP00000009503	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	LOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase.	0.862
BRCA2	BARD1	ENSUMAP00000030927	ENSUMAP00000000975	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	BRCA1-associated RING domain protein 1.	0.967
BRCA2	BRCA1	ENSUMAP00000030927	ENSUMAP00000034948	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.996
BRCA2	BRIP1	ENSUMAP00000030927	ENSUMAP00000030915	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	Fanconi anemia group J protein.	0.964
BRCA2	PALB2	ENSUMAP00000030927	ENSUMAP00000011908	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	Partner and localizer of BRCA2 isoform X1.	0.999
BRCA2	PMS2	ENSUMAP00000030927	ENSUMAP00000012008	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	PMS1 homolog 2, mismatch repair system component.	0.660