STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMYD5SET and MYND domain-containing protein 5. (385 aa)    
Predicted Functional Partners:
SMYD4
SET and MYND domain-containing protein 4 isoform X1.
      
 0.854
SMYD1
Histone-lysine N-methyltransferase SMYD1.
      
 0.789
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.715
ALG1
Chitobiosyldiphosphodolichol beta-mannosyltransferase isoform X1.
 
 
    0.695
SMYD3
LOW QUALITY PROTEIN: histone-lysine N-methyltransferase SMYD3.
      
 0.636
ZNF326
DBIRD complex subunit ZNF326; Belongs to the AKAP95 family.
      
 0.596
WDR91
WD repeat-containing protein 91 isoform X1.
      
 0.550
EED
Polycomb protein EED.
   
 0.525
RBBP5
RB binding protein 5, histone lysine methyltransferase complex subunit.
    
 0.517
ASH2L
ASH2 like, histone lysine methyltransferase complex subunit.
    
 0.516
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.