node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP2A1 | EGFR | ENSUMAP00000008574 | ENSUMAP00000012230 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | Receptor protein-tyrosine kinase. | 0.779 |
AP2A1 | ENSUMAP00000027695 | ENSUMAP00000008574 | ENSUMAP00000027695 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | annotation not available | 0.882 |
AP2A1 | EPS15 | ENSUMAP00000008574 | ENSUMAP00000031920 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | Epidermal growth factor receptor substrate 15. | 0.934 |
AP2A1 | EPS15L1 | ENSUMAP00000008574 | ENSUMAP00000001089 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | Epidermal growth factor receptor substrate 15-like 1. | 0.832 |
AP2A1 | HGS | ENSUMAP00000008574 | ENSUMAP00000022323 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | 0.731 |
AP2A1 | ITSN1 | ENSUMAP00000008574 | ENSUMAP00000027675 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | Intersectin-1 isoform X2. | 0.882 |
AP2A1 | ITSN2 | ENSUMAP00000008574 | ENSUMAP00000031617 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | LOW QUALITY PROTEIN: intersectin-2. | 0.964 |
AP2A1 | REPS1 | ENSUMAP00000008574 | ENSUMAP00000032969 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | ralBP1-associated Eps domain-containing protein 1 isoform X1. | 0.861 |
AP2A1 | STON2 | ENSUMAP00000008574 | ENSUMAP00000008977 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | Stonin-2; Belongs to the Stoned B family. | 0.688 |
EGFR | AP2A1 | ENSUMAP00000012230 | ENSUMAP00000008574 | Receptor protein-tyrosine kinase. | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | 0.779 |
EGFR | EPS15 | ENSUMAP00000012230 | ENSUMAP00000031920 | Receptor protein-tyrosine kinase. | Epidermal growth factor receptor substrate 15. | 0.987 |
EGFR | EPS15L1 | ENSUMAP00000012230 | ENSUMAP00000001089 | Receptor protein-tyrosine kinase. | Epidermal growth factor receptor substrate 15-like 1. | 0.985 |
EGFR | HGS | ENSUMAP00000012230 | ENSUMAP00000022323 | Receptor protein-tyrosine kinase. | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | 0.901 |
EGFR | ITSN2 | ENSUMAP00000012230 | ENSUMAP00000031617 | Receptor protein-tyrosine kinase. | LOW QUALITY PROTEIN: intersectin-2. | 0.528 |
EGFR | STON2 | ENSUMAP00000012230 | ENSUMAP00000008977 | Receptor protein-tyrosine kinase. | Stonin-2; Belongs to the Stoned B family. | 0.431 |
EGFR | WASL | ENSUMAP00000012230 | ENSUMAP00000007214 | Receptor protein-tyrosine kinase. | Neural Wiskott-Aldrich syndrome protein. | 0.419 |
ENSUMAP00000027695 | AP2A1 | ENSUMAP00000027695 | ENSUMAP00000008574 | annotation not available | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | 0.882 |
ENSUMAP00000027695 | EPS15 | ENSUMAP00000027695 | ENSUMAP00000031920 | annotation not available | Epidermal growth factor receptor substrate 15. | 0.926 |
ENSUMAP00000027695 | EPS15L1 | ENSUMAP00000027695 | ENSUMAP00000001089 | annotation not available | Epidermal growth factor receptor substrate 15-like 1. | 0.843 |
ENSUMAP00000027695 | HGS | ENSUMAP00000027695 | ENSUMAP00000022323 | annotation not available | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | 0.646 |