STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TPH1Tryptophan 5-hydroxylase 1. (444 aa)    
Predicted Functional Partners:
PCBD1
Pterin-4 alpha-carbinolamine dehydratase 1.
  
 0.980
PCBD2
Pterin-4-alpha-carbinolamine dehydratase 2.
  
 0.980
DDC
aromatic-L-amino-acid decarboxylase isoform X1.
   
 0.964
QDPR
Quinoid dihydropteridine reductase.
  
 
 0.945
TDO2
Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
  
 
 0.932
TPH2
LOW QUALITY PROTEIN: tryptophan 5-hydroxylase 2.
  
 
 
0.924
IDO2
Indoleamine 2,3-dioxygenase 2.
   
 
 0.924
IDO1
Indoleamine 2,3-dioxygenase 1.
   
 
 0.924
DHFR
Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.
     
 0.904
PAH
Phenylalanine-4-hydroxylase isoform X1.
  
  
 
0.902
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.