CNTN4 protein (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CNTN4

Contactin-4. (1018 aa)

Predicted Functional Partners:

ENSUMAP00000032426

0.730

PTPRG

0.730

APP

0.728

TSNARE1

0.638

LOC103682123

0.636

NFASC

0.610

NRCAM

0.600

CHL1

0.600

RIMS4

0.571

APLP2

0.552

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APLP2	APP	ENSUMAP00000007371	ENSUMAP00000020202	Amyloid-like protein 2.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.592
APLP2	CHL1	ENSUMAP00000007371	ENSUMAP00000033398	Amyloid-like protein 2.	Neural cell adhesion molecule L1-like protein isoform X2.	0.406
APLP2	CNTN4	ENSUMAP00000007371	ENSUMAP00000033410	Amyloid-like protein 2.	Contactin-4.	0.552
APP	APLP2	ENSUMAP00000020202	ENSUMAP00000007371	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Amyloid-like protein 2.	0.592
APP	CNTN4	ENSUMAP00000020202	ENSUMAP00000033410	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Contactin-4.	0.728
APP	PTPRG	ENSUMAP00000020202	ENSUMAP00000032580	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase gamma.	0.422
CHL1	APLP2	ENSUMAP00000033398	ENSUMAP00000007371	Neural cell adhesion molecule L1-like protein isoform X2.	Amyloid-like protein 2.	0.406
CHL1	CNTN4	ENSUMAP00000033398	ENSUMAP00000033410	Neural cell adhesion molecule L1-like protein isoform X2.	Contactin-4.	0.600
CHL1	ENSUMAP00000032426	ENSUMAP00000033398	ENSUMAP00000032426	Neural cell adhesion molecule L1-like protein isoform X2.	annotation not available	0.597
CHL1	NFASC	ENSUMAP00000033398	ENSUMAP00000004400	Neural cell adhesion molecule L1-like protein isoform X2.	Neurofascin isoform X2.	0.466
CHL1	PTPRG	ENSUMAP00000033398	ENSUMAP00000032580	Neural cell adhesion molecule L1-like protein isoform X2.	LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase gamma.	0.597
CNTN4	APLP2	ENSUMAP00000033410	ENSUMAP00000007371	Contactin-4.	Amyloid-like protein 2.	0.552
CNTN4	APP	ENSUMAP00000033410	ENSUMAP00000020202	Contactin-4.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.728
CNTN4	CHL1	ENSUMAP00000033410	ENSUMAP00000033398	Contactin-4.	Neural cell adhesion molecule L1-like protein isoform X2.	0.600
CNTN4	ENSUMAP00000032426	ENSUMAP00000033410	ENSUMAP00000032426	Contactin-4.	annotation not available	0.730
CNTN4	LOC103682123	ENSUMAP00000033410	ENSUMAP00000005811	Contactin-4.	annotation not available	0.636
CNTN4	NFASC	ENSUMAP00000033410	ENSUMAP00000004400	Contactin-4.	Neurofascin isoform X2.	0.610
CNTN4	NRCAM	ENSUMAP00000033410	ENSUMAP00000019652	Contactin-4.	Neuronal cell adhesion molecule.	0.600
CNTN4	PTPRG	ENSUMAP00000033410	ENSUMAP00000032580	Contactin-4.	LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase gamma.	0.730
CNTN4	RIMS4	ENSUMAP00000033410	ENSUMAP00000035391	Contactin-4.	Regulating synaptic membrane exocytosis protein 4.	0.571