STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC103678737Complement C3-like. (1662 aa)    
Predicted Functional Partners:
CFI
Complement factor I; Belongs to the peptidase S1 family.
   
 0.758
CFH
Complement factor H.
   
 0.725
CFB
Complement factor B; Belongs to the peptidase S1 family.
   
 0.712
C1S
Complement C1s subcomponent; Belongs to the peptidase S1 family.
   
 0.707
MASP2
LOW QUALITY PROTEIN: mannan-binding lectin serine protease 2; Belongs to the peptidase S1 family.
   
 0.705
CD55
Complement decay-accelerating factor.
   
 0.697
LOC103673599
Haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
   
 0.691
C9
Complement component C9.
   
 0.690
C6
LOW QUALITY PROTEIN: complement component C6.
   
 0.682
C2
LOW QUALITY PROTEIN: complement C2; Belongs to the peptidase S1 family.
   
 0.675
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.